The continued spread of coronavirus disease 2019 (COVID-19) and the subsequent reactions by governments globally will likely force Mexican drug cartels to turn further toward alternative sources of revenue, which may have significant implications for supply chains in the country. Relevant issues for supply chains in Mexico could possibly include an increased targeting of cargo for illegal drug trafficking and migrant stowaways and trafficking, an uptick in cargo theft conducted by cartels, increased violence affecting company operations,and a more pervasive criminal environment should the government fail effectively provide for citizens.